A community of empowered individuals who believe in, uphold and value human dignity, social justice, integrity of creation, sense of national identity and Divine Providence, De La Salle John Bosco College (DLSJBC) was established in 1963 as the John Bosco Technical High School for boys by the Don Bosco Fathers. The school was located at the former parish convent at Mangagoy and used part of the church as classrooms. In 1967, its first batch of students graduated. The following year, high school girls of nearby St. Margaret Mary's School were transferred to John Bosco. In 1969, John Bosco High School became a coeducational institution through a merger with St. Margaret Mary's School.

In 1977, the administration and supervision of John Bosco was formally turned over to the De La Salle Brothers. In 1997, pre-school, nursery, and kinder levels were opened at John Bosco. It was also in the same year that John Bosco School became John Bosco College with the opening of its College of Education. In 2006, the school was officially accepted as a District school and member of De La Salle Philippines.